Testosterone Treatments May Successfully Reverse Type-2 Diabetes in Some Men

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Diabetes is one of the most common chronic illnesses in the United States, affecting the lives of tens of millions of Americans.

There is a clear link between Testosterone Deficiency and Diabetes, and researchers from the University at Buffalo hypothesize that Testosterone Injections may be an effective addition to Diabetes Treatment.

Not that long ago, Type-2 Diabetes was considered a permanent condition. On the other hand, a growing selection of research shows that Type-2 Diabetes can be greatly mitigated and even reversed with the correct treatment combined with appropriate lifestyle changes.

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Dr. Paresh Dandona Presents New Data Regarding Testosterone as a Type-2 Diabetes Treatment

Dr. Paresh Dandona is the co-author of the research, printed in the scientific periodical Diabetes, Obesity, and Metabolism. The title is "Remission of type 2 diabetes following long-term treatment with injectable testosterone undecanoate in patients with hypogonadism and type 2 diabetes: 11-year data from a real-world registry study."

This study collected data from eleven years of treatment at a facility in Bremerhaven, Germany. Bio-Identical Testosterone Therapy cured Type-2 Diabetes in 1/3rd of treated patients. Based on this data, Dr. Dandona is confident that Testosterone can help men overcome Diabetes, increase insulin sensitivity, and burn body fat. The research is making waves around the world, as Dr. Dandona was highly lauded in India for his research at the 2020 Mohan Diabetes Foundation Symposium.

What is Type-2 Diabetes?

Type-2 Diabetes is a disorder of the pancreatic system which prevents the body from adequately controlling blood sugar. It's also known as Adult-Onset Diabetes or Diabetes Mellitus Type 2.

Blood Glucose Levels elevate because the body can't produce enough Insulin to lower Blood Sugar, largely due to rising insulin resistance. Testosterone Deficiency is common among Type-2 Diabetics, affecting around 1/3rd of men with the condition. It's estimated that more than 3,000,000 are diagnosed with Type-2 Diabetes every year.

The Link Between Type-2 Diabetes and Low-T

Dandona's research team first linked Type-2 Diabetes to Testosterone Deficiency in 2004. They also discovered that 25% of obese males without Diabetes also have Hypogonadism. It's estimated that Obesity and Type-2 Diabetes are the two leading causes of Testosterone Deficiency in men.

Research published in 2016 by Dandona and others showed that Low-T Treatment with Bio-Identical Testosterone could reverse Insulin Resistance in a large cohort of patients. As Low-T has been shown to increase Insulin Resistance, it makes sense that Testosterone Therapy would restore Insulin Sensitivity.

In the most recently published study, the goal was to establish the effects of Testosterone Therapy on patients with comorbid Type-2 Diabetes and Low-T. Researchers sought to analyze the extent to which Testosterone Injection could reduce Insulin Resistance and help control blood sugar. They hypothesized that some patients could be cured of Type-2 Diabetes with effective treatment.

Testosterone Therapy for Type-2 Diabetics - Collecting Data

This study followed the treatment of 356 male patients. The same Urology Clinic treated all patients for eleven consecutive years. All patients were provided with the standard treatment for Diabetes, but 178 patients also received Testosterone Injections.

Of these 178, the average age of the men was 62, and patients received a 1 gram injection of Testosterone Undecanoate once every three months (after a six-week booster). The other 178 patients opted not to receive Testosterone Injections and had an average age of 64.

Patients were thoroughly analyzed regarding various factors associated with health and wellness, including Total Testosterone, Lipid Profile, Heart Rate, Insulin, HbA1c, Resting Glucose, Blood Pressure, waist circumference, weight, and height. Sexual Function and Quality of life were also recorded. Quality of Life was assessed via the Aging Males' Symptoms questionnaire. This data was collected a minimum of two times per year.

Testosterone for Type-2 Diabetes Results

The benefits were abundantly clear for patients receiving Testosterone Injections. Over the course of treatment, patients lost weight, had healthier resting blood sugar, lower resting insulin levels, and had lower HbA1c. On the other hand, patients that opted out of Testosterone had higher fasting insulin, HbA1c, and fasting glucose.

Among the experimental group, over 1/3rd experienced full relief from Diabetes. Furthermore, 46.6% of these patients could control blood sugar with a combo of Testosterone Therapy and Diabetes Treatment.

Among these 178 patients, 83.1% met their HbA1c target. On the other hand, Control Patients experienced no cases of remission and had no reduction in HbA1c or blood sugar.

Patients taking Testosterone for Diabetes also had lower mortality risk and fewer diabetic complications, strokes, or heart attacks. This research makes it clear that the appropriate research should be conducted to ensure that patients with Type-2 Diabetes have access to the best possible treatments to live and thrive.

The study's authors note that 1/3rd of men suffer from Low-T and Type-2 Diabetes simultaneously. While Diabetes can cause Low-T, Testosterone Deficiency exacerbates the symptoms and increases the severity of Diabetes.

The discovery that Testosterone Replacement Therapy can effectively treat Type-2 Diabetes is groundbreaking. Further research is being conducted now and planned in the future to ensure the safety and effectiveness of this treatment.

Reference

https://medicalxpress.com/news/2019-03-testosterone-therapy-hypogonadism-t2dm.html